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Discover everything Scribd has to offer, including books and audiobooks from major publishers. Start Free Trial Cancel anytime. Report this Document Download Now Save Save Receptor Ecp For Later 0 ratings 0 found this document useful (0 votes) 836 views 2 pages Receptor Ecp Uploaded by German Tommasi Description: Full description Save Save Receptor Ecp For Later 0 0 found this document useful, Mark this document as useful 0 0 found this document not useful, Mark this document as not useful Embed Share Print Download Now Jump to Page You are on page 1 of 2 Search inside document Browse Books Site Directory Site Language: English Change Language English Change Language. A base possui duas abas laterais para sua fixacao, guias internos para a acomodacao da placa e orificios na parte inferior, para a saida do cabo flat e do fio da antena. Para obter maior eficiencia na recepcao dos sinais, a antena deve ficar sempre na posicao vertical e afastada de qualquer outra fiacao. Em cada canal existe um rele que fornece contatos “NA”, “CM” (comum) e “NF”. Sao aceitos ate 63 dispositivos (entre controles remotos e sensores), com frequencia de trabalho em 433,92 Mhz, padrao “Code Learning” (protocolo HT6P20B). A distancia media de recepcao dos sinais e de ate 80 metros e a alimentacao do receptor podera ser fornecida atraves de uma fonte de 12 a 24 Vac ou Vdc (corrente continua ou alternada). Em ambos os contatos nao existe tensao ou corrente eletrica, uma vez que o rele apenas conecta “NF” ou “NA” ao “Comum”, conforme ilustracao a seguir: Canal Ativado NA NF CM Canal Desativado NA CM NF Se desejar utilizar este receptor em aplicacoes onde necessite comutar energia (como acionar fechaduras ou outros dispositivos, acender lampadas, etc), conecte-a aos contatos adequados para obter o funcionamento esperado. CUIDADO: Nao ultrapasse os limites de potencia para cada canal (500W em 220V e 300W em 127V).
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Quando programado em modo Pulso, o canal sera mantido acionado pelo tempo em que um botao de controle devidamente cadastrado para este canal (ou botoeira) estiver pressionado. Em modo Retencao, quando um botao de controle cadastrado para um canal (ou botoeira) e pressionado, o estado deste canal e invertido (ativado ou desativado). Caso a operacao de cadastro tenha sido efetuada com exito, o LED “LD1” acendera por 4 segundos. O botao pressionado no controle estara registrado no receptor. Todos os controles cadastrados para ativar o canal selecionado via Strap serao eliminados. ATENCAO: Para apagar TODOS os controles do receptor execute a eliminacao por completo, repetindo o procedimento por 3 vezes, uma vez para cada configuracao de canal. 6) Programando a Operacao do Receptor: Apos cadastrar os controles remotos e necessario definir o modo de operacao do receptor, atraves do posicionamento dos straps de configuracao dos canais. Esta programacao e efetuada atraves dos Straps do Jumper JP1, conforme segue: Canal 1: Retencao; Canal 2: Pulso. CH1 CH2 CH2 CH1 BEEP Canal 1: Pulso; Canal 2: Retencao. JP1 CH2 CH1 BEEP JP1 Canal 1: Retencao; Canal 2: Retencao. BEEP Strap Removido: Canal em modo Retencao. JP1 CH2 CH1 BEEP JP1 Strap Inserido: Canal em modo Pulso. Canal 1: Pulso; Canal 2: Pulso. 7) Configurando a Retencao Temporizada Quando um canal e configurado para operar como “Retencao”, e possivel programar um tempo para que o canal se mantenha ativado e, ao final deste, retorne a posicao inicial. O LED piscara para informar que o tempo foi adicionado. O receptor aguarda, no maximo, 5 segundos entre cada pressionamento da botoeira “Tempo”. Se nenhuma operacao for realizada neste intervalo, o cadastro e cancelado (LED acende por 2 segundos); 4) Ao atingir o tempo desejado, pressione a botoeira “Controle”, para que o tempo seja armazenado na memoria do canal. O tempo para retencao do canal sera eliminado.
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3) Para confirmar a eliminacao do tempo programado, pressione e solte a botoeira de programacao “Controle” do receptor. 8) Beep’s de Sirene O receptor permite programar o Canal 2 para pulsar quando o Canal 1 e ativado ou desativado. Desta forma, o Canal 2 deve ser utilizado exclusivamente para a conexao do dispositivo sinalizador (sirene ou outros). Em caso de defeito no periodo de garantia, a responsabilidade da ECP limita-se ao conserto ou substituicao do aparelho de sua fabricacao. Observacao: A ECP reserva o direito de modificar o conteudo desse manual sem previo aviso. Visite nosso site na Internet: www.ecp.com.br We are a non-profit group that run this service to share documents. We need your help to maintenance and improve this website. Manual Alard Max WiFiDigital Guia de InstalacaoDigital Guia de InstalacaoAo manipular a placa da central de alarme, tome Por se tratar de um fio rigido, a torcao da antena pode danificar a solda que a prende ao circuito e, no caso Procure embutir os fios da central e dos sensores na parede ou faca-os ficar o mais longe possivel das Ele aceita tensoes de 90. Vac a 240 Vac. Veja como realizar as ligacoes eletricas:Rede EletricaRede EletricaBateria nao inclusaDigital Guia de InstalacaoCaso um setor supervisione apenas sensores sem-fio ou nao seja utilizado, e necessario conectar o fio Uti l ize, no AlarmeAlarmeDigital Guia de InstalacaoPoderao ser cadastrados ate 6 numeros Segue abaixo ilustracao para Digital 5.6) Saidas PGM: RETENCAO ou PULSO. Para liga-las a um modulo PGM negativo, podera seguir esta informacao abaixo:Tipo 01Tipo 01Tipo 01Digital Guia de InstalacaoShock. Desta forma, toda vez que for solicitado o arme do setor 1, a PGM3 ativa para armar a Shock e a Para fazer esta Tipo 02Digital Guia de InstalacaoRoteadores de boa qualidade sao essenciais para evitar Alem do mais, e essencial que uma estrutura esteja Para aumentar sua seguranca, uma.
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Discadora Cell em paralelo podera prover algumas notificacoes de alarme, mesmo em caso de falta de Revisao Atual: 01 - Abrange produto ate versao 1.08Acesse nosso canal no YouTube e tire suas duvidas. Canal YouTube: DigitalYouTube Avaliacoes 5 1 avaliacao Excelente 1 Bom 0 Suficiente 0 Fraco 0 Pessimo 0 Organizar por Os mais recentes Avaliacao mais alta Avaliacao mais baixa Os mais recentes marcelo-barone ha 15 dias Apostilas relacionadas Componentes SMD em placas eletronicas. Como fazer Placa eletronica com impressora laser Placaseletronica2016 Tutorial simples e pratico para confeccao de placas de circuitom impresso. Please consider upgrading your browser. UniProtKB - P12724This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. More. - Experimental evidence at protein level i Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. More. Select a section on the left to see content. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. 2 Publications Sites Feature key Position(s) Description Actions Graphical view Length GO - Molecular function i endonuclease activity Source: UniProtKB-KW lipopolysaccharide binding Source: UniProtKB Complete GO annotation on QuickGO. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest. More. Keywords i Molecular function Antibiotic, Antimicrobial, Endonuclease, Hydrolase, Nuclease Enzyme and pathway databases Pathway Commons web resource for biological pathway data More. PathwayCommons i P12724 Reactome - a knowledgebase of biological pathways and processes More.
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Reactome i R-HSA-6798695 ?, Neutrophil degranulation R-HSA-6803157 ?, Antimicrobial peptides See the description of this EC number in ENZYME. ) Short name: ECP Alternative name(s): Ribonuclease 3 Short name: RNase 3 Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'. More. Gene names i Name: RNASE3 Synonyms: ECP, RNS3 The component name refers to the genomic component encoding a set of proteins. More. Component i: Chromosome 14 Organism-specific databases Eukaryotic Pathogen Database Resources More. EuPathDB i HostDB:ENSG00000169397.3 Human Gene Nomenclature Database More. HGNC i HGNC:10046 ?, RNASE3 Online Mendelian Inheritance in Man (OMIM) More. MIM i 131398 ?, gene neXtProt; the human protein knowledge platform More. Keywords - Cellular component i Secreted. DisGeNET i 6037 Open Targets More. OpenTargets i ENSG00000169397 The Pharmacogenetics and Pharmacogenomics Knowledge Base More. PharmGKB i PA34414 Miscellaneous databases Pharos NIH Druggable Genome Knowledgebase More. Pharos i P12724 ?, Tbio Chemistry databases Drug and drug target database More. DrugBank i DB02098 ?, Adenosine-2'-5'-Diphosphate DB04272 ?, Citric acid DB01411 ?, Pranlukast Polymorphism and mutation databases BioMuta curated single-nucleotide variation and disease association database More. BioMuta i RNASE3 Domain mapping of disease mutations (DMDM) More. DMDM i 147744558. Add BLAST 27 MassIVE i P12724 PaxDb, a database of protein abundance averages across all three domains of life More. PaxDb i P12724 PeptideAtlas More. PeptideAtlas i P12724 PRoteomics IDEntifications database More. PRIDE i P12724 ProteomicsDB: a multi-organism proteome resource More. ProteomicsDB i 52864 PTM databases GlyGen: Computational and Informatics Resources for Glycoscience More. GlyGen i P12724 ?, 3 sites iPTMnet integrated resource for PTMs in systems biology context More.Bgee i ENSG00000169397 ?
, Expressed in bone marrow and 111 other tissues Genevisible search portal to normalized and curated expression data from Genevestigator More. Genevisible i P12724 ?, HS Organism-specific databases Human Protein Atlas More. HPA i ENSG00000169397 ?, Group enriched (blood, bone marrow) In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. Protein-protein interaction databases The Biological General Repository for Interaction Datasets (BioGRID) More. BioGRID i 111966 ?, 14 interactors Protein interaction database and analysis system More. IntAct i P12724 ?, 13 interactors STRING: functional protein association networks More. STRING i 9606.ENSP00000302324 Miscellaneous databases RNAct, Protein-RNA interaction predictions for model organisms. More. RNAct i P12724 ?, protein SMR i P12724 Database of comparative protein structure models More. ModBase i Search. Protein Data Bank in Europe - Knowledge Base More. PDBe-KB i Search. Miscellaneous databases Relative evolutionary importance of amino acids within a protein sequence More. EvolutionaryTrace i P12724 Curated Keywords - Domain i Signal Phylogenomic databases evolutionary genealogy of genes: Non-supervised Orthologous Groups More.GeneTree i ENSGT00940000162253 The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms More. InParanoid i P12724 KEGG Orthology (KO) More. KO i K10787 Identification of Orthologs from Complete Genome Data More. OMA i NQSIRCP Database of Orthologous Groups More. OrthoDB i 1482425at2759 Database for complete collections of gene phylogenies More. PhylomeDB i P12724 TreeFam database of animal gene trees More. TreeFam i TF333393 Family and domain databases Gene3D Structural and Functional Annotation of Protein Families More. Gene3D i 3.10.130.10 ?, 1 hit Integrated resource of protein families, domains and functional sites More. PANTHER i PTHR11437 ?, PTHR11437?, 1 hit Pfam protein domain database More.
Pfam i View protein in Pfam PF00074 ?, RnaseA?, 1 hit Protein Motif fingerprint database; a protein domain database More. PRINTS i PR00794 ?, RIBONUCLEASE Simple Modular Architecture Research Tool; a protein domain database More. SUPFAM i SSF54076 ?, SSF54076?, 1 hit PROSITE; a protein domain and family database More.It also includes information pertinent to the sequence(s), including length and molecular weight. The information is filed in different subsections. The current subsections and their content are listed below: More. Sequence i Corresponds to variant dbSNP:rs12147890 Ensembl. 1 Sequence databases Select the link destinations: EMBL nucleotide sequence database More. EMBL i GenBank nucleotide sequence database More. GenBank i DNA Data Bank of Japan; a nucleotide sequence database More. DDBJ i Links Updated X15161 mRNA Translation: CAA33251.1 M28128 mRNA Translation: AAA50283.1 X16545 Genomic DNA Translation: CAA34545.1 X55990 Genomic DNA Translation: CAA39462.1 AF294019 Genomic DNA Translation: AAG31589.1 AF294020 Genomic DNA Translation: AAG31590.1 AF294021 Genomic DNA Translation: AAG31591.1 AF294022 Genomic DNA Translation: AAG31592.1 AF294023 Genomic DNA Translation: AAG31593.1 AF294024 Genomic DNA Translation: AAG31594.1 AF294025 Genomic DNA Translation: AAG31595.1 AF294026 Genomic DNA Translation: AAG31596.1 AL133371 Genomic DNA No translation available. BC096060 mRNA Translation: AAH96060.1 BC096061 mRNA Translation: AAH96061.1 BC096062 mRNA Translation: AAH96062.1 AF441204 Genomic DNA Translation: AAL35279.1 AF441205 Genomic DNA Translation: AAL35280.1 AF441206 Genomic DNA Translation: AAL35281.1 The Consensus CDS (CCDS) project More. CCDS i CCDS9560.1 Protein sequence database of the Protein Information Resource More. PIR i B35328 ?, JL0106 NCBI Reference Sequences More. Ensembl i ENST00000304639 ?; ENSP00000302324 ?; ENSG00000169397 Database of genes from NCBI RefSeq genomes More. GeneID i 6037 KEGG: Kyoto Encyclopedia of Genes and Genomes More.
KEGG i hsa:6037 UCSC genome browser More. UCSC i uc001vyj.4 ?, human Keywords - Coding sequence diversity i Polymorphism PDBe i Protein Data Bank RCSB More. RCSB PDB i Protein Data Bank Japan More. PDBe-KB i Search. Protein-protein interaction databases BioGRID i 111966 ?, 14 interactors IntAct i P12724 ?, 13 interactors STRING i 9606.ENSP00000302324 Chemistry databases DrugBank i DB02098 ?, Adenosine-2'-5'-Diphosphate DB04272 ?, Citric acid DB01411 ?, Pranlukast PTM databases GlyGen i P12724 ?, 3 sites iPTMnet i P12724 PhosphoSitePlus i P12724 Polymorphism and mutation databases BioMuta i RNASE3 DMDM i 147744558 Proteomic databases EPD i P12724 jPOST i P12724 MassIVE i P12724 PaxDb i P12724 PeptideAtlas i P12724 PRIDE i P12724 ProteomicsDB i 52864 Protocols and materials databases Antibodypedia a portal for validated antibodies More. Antibodypedia i 57757 ?, 296 antibodies Genome annotation databases Ensembl i ENST00000304639 ?; ENSP00000302324 ?; ENSG00000169397 GeneID i 6037 KEGG i hsa:6037 UCSC i uc001vyj.4 ?, human Organism-specific databases Comparative Toxicogenomics Database More. CTD i 6037 DisGeNET i 6037 EuPathDB i HostDB:ENSG00000169397.3 GeneCards: human genes, protein and diseases More. BioGRID-ORCS i 6037 ?, 4 hits in 870 CRISPR screens EvolutionaryTrace i P12724 The Gene Wiki collection of pages on human genes and proteins More. GenomeRNAi i 6037 Pharos i P12724 ?, Tbio Protein Ontology More. PRO i PR:P12724 RNAct i P12724 ?, protein The Stanford Online Universal Resource for Clones and ESTs More. ProtoNet i Search. MobiDB: a database of protein disorder and mobility annotations More. MobiDB i Search. These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'. More.
Accession i P12724 Primary (citable) accession number: P12724 Secondary accession number(s): Q4VBC1, Q8WTP7, Q8WZ62, Q9GZN9 See complete history. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Do not show this banner again. Not for use in diagnostic procedures. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual. Certain products may require to ship with dry ice and additional dry ice fee may apply. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing EDNRB. The ELISA analytical biochemical technique of the MBS7249903 kit is based on EDNRB antibody-EDNRB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EDNRB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EDNRB. Quality control assays assessing reproducibility identified the intra-assay CV () and inter-assay CV(). This ELISA kit for research use only. Principle of the Assay: ECP ELISA kit applies the quantitative sandwich enzyme immunoassay technique. The microtiter plate has been pre-coated with a monoclonal antibody specific for ECP.
Standards or samples are then added to the microtiter plate wells and ECP if present, will bind to the antibody pre-coated wells. The microtiter plate undergoes incubation, and then the wells are thoroughly washed to remove all unbound components. Next, substrate solutions are added to each well. The enzyme (HRP) and substrate are allowed to react over a short incubation period. Only those wells that contain ECP and enzyme-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. A standard curve is plotted relating the intensity of the color (O.D.) to the concentration of standards. The ECP concentration in each sample is interpolated from this standard curve. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. I have read and accept the Wiley Online Library Terms and Conditions of Use Shareable Link Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Copy URL Feasibility (defined by the four parameters previously described) of MNCs collection was observed in 1 out of the 30 harvests analysed. This manual will: This manual will: The Administrative Panel on Biosafety and the Biosafety Manager have revised this document based on the latest government regulatory requirements, guidelines and current professional standards. It is designed to inform the laboratory worker of good work practices and safe procedures which are found in most biosafety manuals; however, this manual also emphasizes the regulatory requirements that must be followed and the need for all related research to be conducted in a responsible manner. However, it is the responsibility of each principal investigator to ensure that all lab workers are familiar with the contents of this manual and that these workers and employees are trained to recognize potential related hazards prior to initiation of the research work. Your cooperation with the Administrative Panel on Biosafety and the Environmental Health and Safety Office is essential to comply with the regulatory requirements that our University must follow in order to continue the success of our research endeavors. As this manual addresses biosafety, it should be stated that a Safety Culture is not a secured biological growth media. Safety culture is a part of organizational culture and is often described by the phrase “the way we do things around here”. According to the American Chemical Society, safety culture at an academic institution is a “reflection of the actions, attitudes, and behaviors” demonstrated by the faculty, staff and students concerning safety”.
This means that safety is viewed as an operational priority, because of the benefits thoughtful, safe procedures and attitudes bring to research. Safety’s intrinsic value is seen in better reproducibility and productivity of research, as well as preventing tragic lab accidents that cost lives and knowledge. This chapter is part of a larger conversation about shaping and defining a shared cultural approach, which integrates safety and health seamlessly with the work of our laboratories and classrooms. Encourage reporting by members when identifying and reviewing lessons learned after an incident and using these as teaching opportunities. Involve all lab incidents and near misses. It is generally understood that these are part of an established research environment. However, because of this experience, it is easy to incorrectly equate safety rules with safety and come to believe that adhering to a list of rules equates to being good at safety. Safety should be no different. This starts with recognizing that safety is a fundamental part of the scientific process, adding value by exerting greater control, reducing uncertainty, and increasing the safety and quality of your results or product. The article began with: Stop trying to create it. Researchers just need to do what they are supposed to be doing, what they are told to do, and we will all be safe. I read on. Safety is a part of every culture. Everyone to some degree has, or is influenced by, multiple safety cultures. All researchers know that safety trainings, classes, guidance’s, regulations, compliance approvals, and inspections currently exist and are part of the established research environment. Do these not comprise a Safety Culture.
We must have a Safety Culture gestalt, a whole that is perceived as more than the sum of its parts, that is second nature to all participants, one that will influence the individual decisions carried out when no one is watching- the most important part of cultural reality, safety or otherwise. Not easy, not impossible, certainly doable and vastly rewarding. The following elements (Fig 1) help lay the foundation to build and support a safe and productive research environment: Faculty and other supervisor are urged to include safety on the agenda and incorporate it into their group thinking and practices. Incorporate safety into laboratory procedures. Make sure you have the right protective equipment, engineering controls are working correctly, and researchers are training to safety perform their work. Principal investigators must enforce the established controls in their lab. Encourage reporting by members when identifying and reviewing lessons learned after and using these as teaching opportunities. Involve all lab incidents and near-misses. While this is an accepted and valuable model of research organization, there are often two potential issues associated with this arrangement: (1) the delegation involves responsibility but may have little or no authority or power to enforce practices, and (2) communication between the PI and Manager can be affected by numerous demands on PI time. Mindfulness of these issues assists in developing and maintaining a strong and healthy research environment. Some key aspects of effective delegation include matching the correct skill level to the task, having firm goals, and providing solid support. The natural progression, if you’re successful, is to become head of your own lab and stop spending time at the bench. There just isn’t time or bench space for it anymore: All your time is spent (between teaching gigs and committee meetings) obtaining and managing money and hiring and managing people.
You’re no longer a scientist; you’re a manager of scientists and your own scientific enterprise. And what training did you get for that?” -Jim Austin, Nov. 9, 2007, “Special Feature: Laboratory Management”, Science ( ). Not only does a thorough risk assessment allow researchers to systematically identify and control hazards, but it also improves the quality of science through more thorough planning, a better understanding of the variables, and by sparking creative and innovative thinking. Failure to consider risk and hazards from the beginning of experimental design can produce delays, roadblocks, and frustration later in the process. What question(s) are you trying to answer. Conduct a broad review of the literature. Speak with others who have done similar work. Are the risks different for different approaches? This may include a deeper dive into specific topics in the literature. Determine hazards associated with each step, and control measures for reducing risk.Question the importance of each step. Seek advice from others. Ask yourself “what could go wrong?”. Have I missed anything. Consider all possible outcomes, how high is the risk? Can you perform a dry run to familiarize yourself with equipment and procedures. Can you test your experimental design at a smaller scale or with a less hazardous material. Determine if any design changes are needed. Run your experiment and monitor how your controls perform. Assess as you go and make changes as needed. It is important to realize that following these guidelines is the responsibility of all investigators at Stanford University and not solely that of investigators that are funded by NIH. One of the most important categories is the Exempt category. To determine if your experiments are exempt, you can check Section III, Category F in the NIH Guidelines (online); a short reference guide is presented in Table 1 and 2. More importantly, the class of gene insert can change the Biosafety level of the construct.
If your experiment does not fall within the exempt categories, you must have current APB approval (also see Table 2). MMLV, Moloney murine leukemia virus; SIV, simian immunodeficiency virus.Ecotropic generally means able to infect only cells of the species originally isolated from or identified in. Please note that the ecotropic host for HIV and HSV would be human cells, but the ecotropic host for MMLV would be murine cells. Amphotropic and VSV-G-pseudotyped virus host range includes human cells.Please note that there are differences in the containment level for the same class depending on whether the viral vector integrates into the recipient genome at a high rate. This does not include SV40 T antigen. SV40 T-antigen-containing cells should not be considered more hazardous than the intact virus. SV40 is considered a risk level 1 agent (the lowest level) according to the NIH Guidelines. The prevalence of SV40 infection in the U.S. population due to contaminated polio vaccine does not seem to have caused a statistically significant increase in the rate of cancers. However, the data from the various studies on SV40 association with cancer are equivocal (Strickler et al. 1998; Butel and Lednicky, 1999; Dang-Tan et al., 2004). d This is a general assessment of containment levels for laboratory construction and use of these vectors for nonproduction quantities only based on the 4th edition of BMBL. This table cannot cover every potential use within a research or laboratory settings; as information is gained, risk assessments and containment levels may be changed. Local IBCs should use all available information and their best judgment to determine appropriate containment levels.These technologies can be used to create gene drives, a modification of an organism’s genome resulting in a more efficient spread of a trait through the population as compared to Mendelian inheritance.